Introduction

> Hardships reveal true friendships, showing who would stand by you in tough times. "Don't eat with people you wouldn't starve with." It's about surrounding yourself with those who truly support you.

Quitting and evolving

> When it comes to walking away from podcasting or any field, it's important to recognize when you've reached a point where you can contribute by mentoring the next generation. Like in skateboarding, where veterans like Tony Hawk supported young talent, transitioning to a mentor role can be a fulfilling part of one's journey.

> Listening to your inner voice and making decisions that may seem unconventional to others, like Grigori Perelman walking away from mathematics and rejecting awards, can lead to a more authentic and fulfilling path. It's about doing what feels right for you, even if it goes against societal expectations or norms.

How to focus and think deeply

> One key insight I shared with Lex was about the power of stilling the body while keeping the mind active, similar to rapid eye movement sleep. I gave examples of high achievers like Rick Rubin and Karl Deisseroth who practice this, leading to great ideas and creativity.

> Another point I highlighted was the relationship between sleep, creativity, and problem-solving. I discussed the rebound effect in rapid eye movement sleep after sleep deprivation, emphasizing its role in generating ideas and boosting creativity, as discussed in a podcast episode with Matt Walker.

Cannabis drama

> Cannabis withdrawal can lead to intense dreaming post-insomnia. The controversial cannabis episode sparked drama in the scientific community over potential health risks, including psychosis from high THC strains for certain individuals.

> Handling online criticism with diplomacy and openness. Inviting a critical guest for a constructive discussion shows a commitment to exploring different perspectives in a respectful manner, despite initial online confrontations.

> Emphasizing the importance of respectful behavior in scientific discourse. Maintaining composure online and promoting intellectual humility can set a positive example for how scientists engage with each other and the public, encouraging constructive dialogue over aggression.

Jungian shadow

> Meeting James Hollis was a transformative experience for me. His wisdom and insights on self-reflection and accessing the unconscious mind had a profound impact. His message about taking time to pause from the constant stimulus and response cycle resonated deeply with me.

> Exploring the concept of the shadow, the hidden aspects of ourselves, is crucial for personal growth. Hollis's emphasis on recognizing our shadows and bringing them to light for self-growth and understanding is invaluable. It's essential to acknowledge and address these hidden parts to evolve.

> Engaging in creative practices slightly different from our main work can be a powerful catalyst for generating ideas. I find that activities like drawing anatomical diagrams spark creative inspiration and lead me to explore new topics, such as autonomic control. Embracing this 15-degree shift from the usual can unlock fresh perspectives and insights.

Supplements

> Experimentation with peptides is key for me, like Pinealon, affecting my circadian rhythm subtly. I try one thing at a time, feeling its effects right away. I avoid heavy hormonal peptides after quick trials; deep sleep disrupts my REM sleep.

> I'm cautious with peptides, not chasing extreme performance goals. Hydration, electrolytes, caffeine from mate and coffee suffice. I stick to simple strategies, like Nicorette for discussion, steering clear of complex peptide cocktails.

Nicotine

> Nicotine can have cognitive benefits but must be used cautiously, "I will only allow myself two pieces of Nicorette total per week." It can enhance focus by affecting acetylcholine release in the brain, leading to a heightened state of attention and concentration.

> Nicotine's effects on the body, like vasoconstriction, can have unexpected outcomes, "Apparently, it helps Tucker Carlson keep his love life vibrant." It's crucial to limit use, especially for individuals under 25 due to the brain's plasticity; while vaping may be safer than smoking, it still poses risks worth considering.

Caffeine

> Caffeine timing is key to avoid afternoon crashes. Delaying caffeine intake in the morning can help offset energy dips later in the day, especially if combined with a smaller lunch and good sleep. Hydration and caffeine first thing in the morning, especially before working out, can set the tone for sustained energy throughout the day.

> Starting exercise early in the morning, even when feeling tired, can provide long-lasting energy. Waiting until later, when energy peaks, to exercise may lead to afternoon exhaustion, impacting cognitive performance during key work hours. The key is to jumpstart your day with physical activity to enhance productivity and mental clarity.

Math gaffe

> Entrainment is a powerful phenomenon that helps in becoming a morning person and explains why we can wake up before our alarms. Creating anticipatory circuits by consistent habits can boost productivity and well-being.

> Embracing mistakes as teaching moments is crucial. Acknowledging and correcting errors, such as in math calculations or scientific concepts, not only clarifies misunderstandings but also allows for growth and learning opportunities.

> Striving for accuracy while navigating controversial topics like oral health, supplements, and pharmaceuticals is challenging. Seeking diverse perspectives, checking with experts, and addressing misconceptions help in providing well-rounded and evidence-based information.

> Encouraging a balanced and nuanced approach to health discussions is essential. Avoiding extreme views and embracing the complexity of topics such as medication effects or lifestyle interventions can foster a more constructive dialogue and understanding in public health education.

2024 presidential elections

> One key insight from the interview is the importance of long-form conversations in politics. "Because what happens when the interview's a little bit too short... You get a set of questions... You don't get to really feel the human, expose the human to the light in the full."

> Another interesting point highlighted is how people's political leanings can surprise us in intimate settings. "When you get people one-on-one... about half the people in the room... will tell you exactly who they wanna see win the presidential race."

Great white sharks

> One thing I've learned from my deep dive into shark behavior is how to interact with them in the water. Swimming towards a shark can change its perception of you from prey to predator, which is pretty fascinating.

> I had a scary experience cage exiting with great white sharks, which made me reassess taking risks with my life. It was a reminder of the importance of safety and understanding wildlife behavior.

> Despite the dark aspects of shark encounters, I am constantly amazed by the agility and power of these creatures. Their visual system, electro-sensing abilities, and coordinated hunting tactics are truly remarkable. Nature is both beautiful and full of wonders, even in the midst of danger.

Ayahuasca & psychedelics

> My ayahuasca journey was transformative. It allowed me to let go of external pressures and truly experience the present moment without distractions.

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> Time perception and our connection to sunlight are deeply rooted in our biology. Understanding how our brains respond to different wavelengths of light can give us insights into our circadian rhythms and cognitive abilities.

> Psychedelics like ibogaine can offer unique introspective experiences that may help individuals address past traumas and mental health issues, making them invaluable tools for therapy and personal growth.

> Exploring the natural world, from diverse animal species to the vibrant life in the jungle, can inspire awe and curiosity, reminding us of the beauty and complexity of life around us. Whether through nature photography or personal experiences in nature, embracing the richness of the world can lead to profound insights.

Relationships

> One of the things on my bucket list is heading to a cabin to work on writing my book, a new experience I'm excited about.

> Finding love and building a family is a priority for me. Advice I received emphasized the importance of choosing the right partner and enjoying the gift of having kids and creating a legacy.

> My future plans involve living in a major city like New York for a new experience and having a place in a rural area like Colorado or Montana for a different lifestyle. The diversity and energy of cities like New York fascinate me, offering contrasting experiences to explore.

Productivity

> I find it crucial to track daily activities, even if just for 5 minutes, ensuring I get things done. "So I have a rule for myself that I do a set of tasks for at least five minutes every day." It's a small commitment that often leads to longer engagement with the task.

> Deep focus is key for me, especially in the mornings. "I'm trying to hit the four-hour mark of deep focus." It's tough, but those morning hours are precious for prioritizing and accomplishing important work.

> Balancing deep work with social interactions can be challenging. "As an individual contributor, to get stuff done, to do the hard work... you need the hours of deep work." Yet collaboration with a great team is essential for achieving meaningful goals.

Friendship

> One key insight I shared with Lex is about the importance of surrounding yourself with loyal friends. As Conor McGregor said, "Don't eat with people you wouldn't starve with." Loyalty is crucial in relationships because it defines the essence of life and who stands by you during hardships.

> Another point I emphasized is that hardships can be a gift. They not only reveal who your true friends are but also make you stronger. I appreciate Lex for inspiring me to start the podcast, being a supportive friend during challenging times, and showing up in various aspects of my life.